Response to Lynch

G Lynch

meant by "more effective." This unqualified assertion is likely to confuse the many people who already use or recommend All-Bran as an "effective" means of avoiding constipation whatever its soluble:insoluble fibre ratio or influence on plasma lipids, mineral absorption, faecal bulking, bowel transit time, etc. Furthermore, it is difficult to see why "wholemeal bread and crispbreads" are the on...

Sean Lynch ,

Diagnosing Lynch syndrome

R isk stratification is essential for designing efficacious and cost effective colon cancer screening programmes. One of the most important risk factors for colorectal cancers (CRC) is an inherited predisposition, implicated in 20% of all cases. The spectrum of genetic susceptibility ranges from the low penetrance mutations that modestly increase the colon cancer risk (for example, I 1307K) to ...

Lynch syndrome (HNPCC)

Lynch syndrome, also referred to as hereditary non-polyposis colorectal cancer (HNPCC), accounts for somewhere between 2 and 5% of all CRC. It has been shown that Lynch syndrome (LS) is a result of germline mutations in genes involved in DNA mismatch repair (MMR) MSH2, MLH1, MSH6, and PMS2, whereas as HNPCC refers to families that adhere to the Amsterdam criteria or iterations of it. More recen...

Lynch ’ s Metaphysical Pluralism

Pluralism, according to Michael P. Lynch, is the thesis that there are or can be more than one true story of the world; there can be incompatible but equally acceptable accounts of some subject matter.’ The opposite view, absolutism, states that there can be only one true story about how the world is. In our ordinary lives both theses have intuitive pull. Most of us are ready to say that there ...